4201 Main Street

Whether you’re a freelancer, a growing startup, or an established company, this thoughtfully designed workspace caters to businesses of all sizes. From open coworking areas to private offices and meeting rooms available by the hour or day, our space gives you the flexibility to work the way you want. Enjoy all-inclusive amenities like fast, secure Wi-Fi, craft coffee and tea, unlimited printing, snacks, and 24/7 access to keep you productive around the clock.

Welcome to 4201 Main Street within the Ion—Houston’s HQ for innovation! Located in the Ion District, powered by Rice University, this is the heart of Houston’s innovation corridor in midtown. The iconic revived building is equipped with a fitness center, multiple food and beverage locations, and common networking areas amongst its 266,000 square feet. At the center of the building is a ted-style space, where annually hundreds of tech and startup focused events and programming are hosted—providing coworking members a chance to scale and grow alongside other leading startups and corporations. Echoing the collaborative and entrepreneurial history of the Ion, we offer one-of-a-kind private suites, offices, and luxe common areas to help welcome and empower teams.